Login / Register

Username:


Password: [Lost?]



New User? Click here for your FREE subscription



School and Community Healthcare Professionals
School and Community Healthcare Professionals Post a healthcare recruiting ad

Follow Us


NEWS-Line on Twitter NEWS-Line on Facebook NEWS-Line on Google+ NEWS-Line on LinkedIn NEWS-Line on Pinterest


School and Community Healthcare Conferences &
Educational Opportunities






Arterial Stiffness May Cause And Worsen Heart Damage Among Adolescents By Increasing Blood Pressure And Insulin Resistance | NEWS-Line for School and Community Healthcare Professionals

Arterial Stiffness May Cause And Worsen Heart Damage Among Adolescents By Increasing Blood Pressure And Insulin Resistance


Source:

Arterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study. The study was conducted in collaboration between Texas Children's Hospital and Baylor College of Medicine in the US, the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland, and the results were published in Atherosclerosis.

Left ventricular hypertrophy and left diastolic dysfunction are measures of structural and functional heart damage, which have been associated with an increased risk of cardiovascular-related death in adults. These cardiac measures are also used in the paediatric population as indicators of premature heart damage.

Arterial stiffness estimated from carotid-femoral pulse wave velocity has been discovered as a novel cause of increased blood pressure, insulin resistance, and metabolic syndrome in adolescents and young adults. It was also recently shown that increased blood pressure in adolescence may cause premature heart damage, but it is not known whether arterial stiffness could independently cause structural and functional damage to the heart.

The current study was conducted among 1,856 adolescents of whom 1,011 were female. The adolescents were 17 years old at baseline, and they were followed up for 7 years until young adulthood at age 24 years. Arterial stiffness, carotid intima-media thickness, and evidence of heart damage were assessed at baseline and follow-up. Signs of heart structure damage are left ventricular hypertrophy and high relative wall thickness, whereas signs of heart function damage are left ventricular diastolic dysfunction and increased left ventricular filling pressure.

During the 7-year follow-up period, the prevalence of heart structural damage among adolescents doubled. With extensive control for fat mass, muscle mass, glucose, insulin, blood pressure, lipids, smoking status, sedentary time, physical activity, socio-economic status, and family history of cardiovascular disease, and using adults’ cut points for diagnosing heart damage, it was observed that adolescents in the highest tertile category of arterial stiffness and carotid intima-media thickness had a 23 – 27% increased risk of progressively worsening structural heart damage.

Only arterial stiffness appears to independently cause both structural and functional heart damage, whereas increased carotid wall thickness does not seem to have a causal role. Increased carotid wall thickness is an early indicator of atherosclerosis, whereas increased arterial stiffness describes arteriosclerosis. The study further reported that arterial stiffness caused heart damage by increasing blood pressure and insulin resistance. The increase in blood pressure explained 34% of the heart damage caused by arterial stiffness. Moreover, insulin resistance explained 15% of the heart damage caused by arterial stiffness.

“We are seeing for the first time that arterial stiffness is a novel cause of several diseases such as hypertension, insulin resistance, metabolic syndrome, and heart damage in the young population. Among adults, arterial stiffness is currently being established as a cause of type 2 diabetes. We discovered that approximately 50% of the deleterious role of arterial stiffness in causing heart damage is enhanced by the mechanism of increased blood pressure and insulin resistance. Thus, preventing and lowering blood pressure and insulin resistance may potentially diminish the negative impact of arterial stiffness on the heart, by up to half,” says Andrew Agbaje, a physician and clinical epidemiologist at the University of Eastern Finland.

“Experimental and clinical intervention studies are urgently needed on comprehensive approaches to treating and reversing arterial stiffness from adolescence. At least, targeting blood pressure and insulin resistance leaves the problem half-solved,” Agbaje continues.

Dr Agbaje’s research group (urFIT-child) is supported by research grants from Jenny and Antti Wihuri Foundation, the Finnish Cultural Foundation Central Fund, the Finnish Cultural Foundation North Savo Regional Fund, the Orion Research Foundation, the Aarne Koskelo Foundation, the Antti and Tyyne Soininen Foundation, the Paulo Foundation, the Yrjö Jahnsson Foundation, the Paavo Nurmi Foundation, the Finnish Foundation for Cardiovascular Research, Ida Montin Foundation, Eino Räsänen Fund, Matti and Vappu Maukonen Fund, and the Foundation for Pediatric Research.

For further information, please contact:

Andrew Agbaje, MD, MPH, Cert. Clinical Research (Harvard), Principal Investigator (urFIT-child). Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland. [email protected], +358 46 896 5633

Honorary Research Fellow – Children's Health and Exercise Research Centre, Public Health and Sports Sciences Department, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. [email protected]

https://uefconnect.uef.fi/en/person/andrew.agbaje/

Link to the article:

Agbaje AO, Zachariah JP, Tuomainen TP. Arterial Stiffness but not Carotid Intima-Media Thickness Progression Precede Premature Structural and Functional Cardiac Damage in Youth: A 7-Year Temporal and Mediation Longitudinal Study. Atherosclerosis August 3, 2023. https://doi.org/10.1016/j.atherosclerosis.2023.117197

Webpage:

urFIT-CHILD Research group

https://news.cision.com/university-of-eastern-finland/r/arterial-stiffness-may-cause-and-worsen-heart-damage-among-adolescents-by-increasing-blood-pressure-,c3817741

Source & Image: University of Eastern Finland




Post not cached because it doesn't exist


Share This!


School and Community Healthcare Jobs


Occupational Therapist

Helena Public Schools
Helena, Montana

Developmental Interventionist, Early Intervention - Part Time - Hourly pay rate: $57.51

The Arc of Union County
Springfield, New Jersey

SPEECH-LANGUAGE PATHOLOGIST - AAC OPPORTUNITY in an Article 16 Clinic,

Shield Institute
Bayside, New York

Occupational Therapist - I/DD Opportunity

Shield Institute
Bayside, New York

Director, Healthcare Supports, Clinical - Full Time 40 hrs - Salary $95,000

The ARC of Union County
Springfield, New Jersey

Smart Start Enrichment Program - Lead Teacher - 4 Month Job Assignment - $30/hr.

The ARC of Union County
Springfield, New Jersey

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.