Login / Register

Username:


Password: [Lost?]



New User? Click here for your FREE subscription



Emergency & Urgent Care Providers
Emergency & Urgent Care Providers Emergency & Urgent Care Providers

Follow Us


NEWS-Line on Twitter NEWS-Line on Facebook NEWS-Line on Google+ NEWS-Line on LinkedIn NEWS-Line on Pinterest


Emergency Care Conferences &
Educational Opportunities



Jan. 31 - Feb. 2

TAPA 2020 Annual CME Conference

Texas Academy of Physician Assistants

April 21 - 24

Atlanta CME Conference

Skin, Bones, Hearts & Private Parts

May 13 - 15

ANCC National Magnet Conference

American Nurses Credentialing Center

May 16 - 20

AAPA 2020 Conference

American Academy of PAs

June 9 - 12

Destin CME Conference

Skin, Bones, Hearts & Private Parts

More Events

Potent Antimicrobial Found That Shows Promise In Fighting Staph Infections | NEWS-Line for Emergency & Urgent Care Providers

Potent Antimicrobial Found That Shows Promise In Fighting Staph Infections


Source:

Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections.

The discovery is important as it is directly related to the development of Staphylococcus aureus diseases, known popularly as staph infections, which are the leading cause of the growing global danger of antimicrobial resistance, particularly the Methicillin-resistant (MRSA) strains which are becoming resistant to all current antibiotics.

“This antimicrobial has a very exciting mode of action, kind of like hitting many birds with one stone,” said Eric Brown, senior author and a professor of biochemistry and biomedical sciences at McMaster. “This provides a promising starting point.”

After screening thousands of small molecules, the research team discovered a potent new antimicrobial they are calling MAC-545496 that is active against MRSA. Unlike conventional antibiotics, this new antimicrobial neither kills the staph infection nor halts its growth on its own, so the potential for antimicrobial resistance may be considerably lessened.

MAC-545496 cripples MRSA’s ability to cause infection by diminishing its tolerance to the hostile components of the immune system and blocking the bacterium’s capacity to resist the action of several front-line antibiotics.

To be more specific, the antimicrobial disarms MRSA from an important protein called GraR which enables the staph infection to respond to external threats, and allows the immune system to clear the infection more effectively. It also inhibits the ability of the MRSA to resist treatment by antibiotics.

First author Omar El-Halfawy, a postdoctoral fellow of biochemistry and biomedical sciences at McMaster, added: “We screened about 45,000 different compounds and found this potent bioactive, it’s the needle in the haystack. But, although it will be a long road between this discovery and clinical use, we feel we’re expanding our arsenal for combatting drug-resistant staph infections.”

The study, published today in the journal Nature Chemical Biology, was funded by the Canadian Institutes of Health Research and GlycoNet, the Canadian Glycomics Network which is one of the federally-supported networks of centres of excellence of Canada.

Source:McMaster University

Photo Credit:McMaster University

Pictured:Eric Brown (left), professor of biochemistry and biomedical sciences, and Omar El-Halfawy, a postdoctoral fellow of biochemistry and biomedical sciences, at McMaster University







Share This!


Emergency Care Jobs



Nurse Manager

Four Winds Hospital
Katonah, New York

Respiratory

Baptist Health
Alabama

Medical Laboratory Scientist

Baptist Health
Alabama

Radiology

Baptist Health
Alabama

Full-Time RN/LPN & Part-Time RN/LPN

Chi St Alexius Health Garrison Hospital
Garrison, North Dakota

Ultrasound, Mammography and Radiologic Technologists

CareMount Medical, P.C
New York

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.