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Penn Scientists Develop 20-Subtype mRNA Flu Vaccine to Protect Against Future Flu Pandemics
An experimental mRNA-based vaccine against all 20 known subtypes of influenza virus provided broad protection from otherwise lethal flu strains in initial tests, and thus might serve one day as a general preventative measure against future flu pandemics, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.
The “multivalent” vaccine, which the researchers describe in a paper published today in Science, uses the same messenger ribonucleic acid (mRNA) technology employed in the Pfizer and Moderna SARS-CoV-2 vaccines. This mRNA technology that enabled those COVID-19 vaccines was pioneered at Penn. Tests in animal models showed that the vaccine dramatically reduced signs of illness and protected from death, even when the animals were exposed to flu strains different from those used in making the vaccine.
“The idea here is to have a vaccine that wi
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Dr. Fauci Reflects On The Perpetual Challenge Of Infectious Diseases
Once considered a potentially static field of medicine, the discipline of studying infectious diseases has proven to be dynamic as emerging and reemerging infectious diseases present continuous challenges, Anthony S. Fauci, M.D., writes in a perspective in the New England Journal of Medicine. In the piece, Dr. Fauci, who since 1984 has directed the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, reflects on his career responding to infectious disease threats. Dr. Fauci will step down from his positions as NIAID director, chief of NIAID’s Laboratory of Immunoregulation and chief medical advisor to President Joe Biden in December 2022.
In the perspective, Dr. Fauci notes that the emergence of HIV/AIDS in 1981 led to a sharp increase in interest in infectious diseases among people entering the field of medicine. Since then, inf
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More Than A Quarter Of U.S. Adults Say They’re So Stressed They Can’t Function
Americans are struggling with multiple external stressors that are out of their personal control, with 27% reporting that most days they are so stressed they cannot function, according to a poll conducted for the American Psychological Association.
A majority of adults cited inflation (83%), violence and crime (75%), the current political climate (66%), and the racial climate (62%) as significant sources of stress.
The nationwide survey, fielded by The Harris Poll on behalf of APA, revealed that 70% of adults reported they do not think people in the government care about them, and 64% said they felt their rights are under attack. Further, nearly half of adults (45%) said they do not feel protected by the laws in the United States. More than a third (38%) said the state of the nation has made them consider moving to a different country.
More than three-quarters of adults (76%) said tha
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Bloating Common Issue Among Americans, Study Reports
Nearly 1 in 7 Americans experience bloating on a weekly basis, and most aren’t seeking professional care for it, according to a new study led by Cedars-Sinai investigators. The findings are published in Clinical Gastroenterology and Hepatology.
"Although bloating is a common symptom, some patients may not bring it up with their doctors," said Janice Oh, MD, a resident physician within the Division of General Internal Medicine Division at Cedars-Sinai and first author of the study. "It’s important that people feel comfortable discussing bloating because it could be a symptom of a serious condition and there are treatments available."
Bloating can make people feel swollen or tight in the abdomen. It may occur when a person’s gastrointestinal tract fills with air or gas and can sometimes be the result of diet or an underlying condition, such as irritable bowel syndrome, carbohydrate enz